Possible New Hair Loss Cure

"Triarco”, a Bio-Tech company based in New Jersey, released some very intriguing results of a pilot study for their patented prostate product Alphastat®, which inhibits 5-alpha reductase. The three-month study on male patients ages 55-68 reported a 40% decrease in blood levels of DHT, which has some obvious implications for treating hair loss.

      In addition to improved Urogenital symptoms, there were, unlike Proscar and Avodart, reports of increased, not decreaesd sexual function.

      As you know, pharmaceutical 5 alpha reductase inhibitors prevent balding and promote hair growth by lowering serum DHT. The documented side effects of pharmaceutical 5 alpha reductase inhibitors include sexual dysfunction, reduced libido, and depression. There were evidently no reports of any negative side effects in this study.

      Triarco stated “We are very pleased with the results of this clinical study because it confirms the results of the pre-clinical studies and is, to our knowledge, the first natural product shown to lower PSA and serum DHT levels in humans."

      If you follow our updates you may already know that consumption of Soy Isoflavones, particularly with Black and Green Tea Extracts, lowers serum DHT as well.

      In addition to its effects on reducing serum DHT, Alphastat also raises testosterone, and lowers estradiol. Alphastat is a combination of the caratenoid Astaxanthin and Saw Palmetto Extract.


Study Summation

      The investigators gave 40 healthy male subjects between the ages 40 and 70, 800 mg or 2g of Alphastat, for two weeks. Below you can evaluate the effect of both dosages on the concentration of serum testosterone in the blood of the test subjects.


More importantly for hair growth, both dosages rapidly reduced serum DHT, as noted below.


Estradiol level was reduced as well, with the smaller dose being slightly more effective than the larger dose (see below).

The study appears to be scientifically valid, with a sufficient sample size of 42 males, measurable blood tests, and sound statistical methodology. It was published in a peer-reviewed scientific journal. This means that at least two independent researchers have reviewed the article and deemed it to be fit for publication



Comment

      There is no evidence suggesting Saw Palmetto per se, has any effect whatsoever on Testosterone levels or serum DHT levels (Saw Palmetto *does* moderately inhibit DHT binding to receptors). The desirable effects on hormone blood levels produced in this study are due to Astaxanthin.

      Astaxanthin is also documented to reduce bodyfat, increase stamina, and maintain glycogen stores in animal models.


Dissecting Alphastat Ingredients

Alphastat® is comprised of 200 mg of a “patented complex” of Saw Palmetto Extract extract and Haematococcus pluvialis algae extract, providing free fatty acids and Astaxanthin.

      Saw Palmetto Extract is typically used at about 300 mg, so it is likely that most of this complex is Saw Palmetto Extract.

      Astaxanthin is a relatively expensive supplement and is generally available in 2 to 4 mg capsules.

      Given the listed ingredients, this “patented complex” is likely about 200 mg Saw Palmetto Extract, and about 2-4 mg Astaxanthin.

      Alphastat also includes 15 mg of zinc monomethionine (OptiZinc) which is a known inhibitor of aromatase.


Alphastat at a higher dose for a fraction of the price

      By utilizing three separate products: “Super Saw Palmetto Extract”, “Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G” and OptiZinc , one can have the benefits of Alphastat for a fraction of the cost, with larger amounts of each ingredient.

      Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G is a combination of caratenoids that in addition to providing 6 mg of Astaxanthin, provides 38 mg of Lutein, 3.75 mg of Meso-Zeaxanthin, and 2.2 mg of C3G ( European) Black Currant Extract. These additional ingredients, in combination with Astaxanthin, prevent against age related vision loss, macular degeneration, and function as an internal UV protectant to damage to skin caused by ultra-violet light, while simultaneously promoting tanning. In addition to raising testosterone, lowering DHT, and estrogen, it markedly reduces the production of wrinkle- and sag-inducing skin enzymes.

      Both "Super Saw Palmetto” and the multi-component “Ultra Natural Prostate Formula” are rich in bioactive, high-molecular weight compounds including beta-sitosterol, which has been shown to interfere with peripheral DHT receptor binding activity.

      DeepExtract™ used in both Super Saw Palmetto and the Ultra Natural Prostate Formula, is a patented, ultra-high pressure CO2 technology engineered to recover far greater amounts of bioactive, high-molecular weight fatty acids from the saw palmetto berry during the extraction process. The result is a superior formula containing key ingredients in higher concentrations than other commercially available extracts. DeepExtract™ ensures the most desirable and complete bioactive extract profile available.


Optizinc is the most bio-available form of Zinc. Zinc has been used as a standalone treatment for acne, which like balding, is an androgen mediated disorder. Like Astaxanthin, it also has an aromatase inhibiting property as well.    

      By using Alphastat, or by combining the three aforementioned ingredients, one can effectively lower DHT, inhibit its binding to receptors, raise testosterone and reduce estradiol, which has significantly positive implications for prostate health, skin aging, vision protection, and of course, hair loss.


New Recommended Treatment Compound:    

Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G

Stem Cell Baldness Cure Actually Works

Here is some news for those waiting to find out results of the stem cell baldness cure.  They have done it!(I think)

Japanese researchers have successfully grown hair on hairless miceby implanting follicles created from stem cells, they announced Wednesday, sparking new hopes of a cure for baldness.

Led by professor Takashi Tsuji from Tokyo University of Science, the team bioengineered hair follicles and transplanted them into the skin of hairless mice.

The creatures eventually grew hair, which continued regenerating in normal growth cycles after old hairs fell out.

When stem cells are grown into tissues or organs, they usually need to be extracted from embryos, but Tsuji and his researchers found hair follicles can be grown withadult stem cells, the study said.

"Our current study thus demonstrates the potential for not only hair regeneration therapy but also the realisation of bioengineered organ replacement using adult somatic stem cells," it said.

The combination of the new and existing technologies is expected to improve treatment for baldness, possibly allowing people to use their own cells for implants that will give them their hair back.

"We would like to start clinical research within three to five years, so that an actual treatment to general patients can start within a decade," said researcher Koh-ei Toyoshima.

The study is published in the online science magazine Nature Communications.

The above seems like great news and would make hair transplantation better because it would allow unlimited donor hair.  If this actually works, then the last problem to solve would be the artistry and skill of the surgeon.  

Stem Cell Hair Loss Remedy

Image via Wikipedia

I sure I'm not the only one dreaming of a stem cell hair loss remedy. It seems stem cells are the supposed cure to everything we can possibly imagine, or so they say but like many men (and women) suffering from hair loss, I'm keeping my eyes peeled for any news on the subject.

I've read stem cell hair loss studies with big words, long descriptions, doctors' names I can't pronounce and they all say there is great promise for a stem cell hair loss remedy but it's a long way off. Well, I hate waiting so I try and find anyone using the technology that works and try and get some. I was surprised to see that there is a stem cell hair loss cream available and it's not that expensive.

Now like any guinea pig, I tried to do as much research on the company and the doctor behind this stem cell hair loss cream but must of what I found was either old, or rather negative. Nobody says the product is harmful, but nobody says it works either. But I say, I've been globbing all kinds of crap on my head for years and I'm still kickin, so what the hell.

Now I'm not gonna name the stuff but I'm sure people out there will want to know what it is and where to get it. You can leave a comment or contact me and I will be happy to share but I'm not trying to sell anything so putting the name of my secret stem cell hair loss cream in this post might lead people to think I'm some type of scammer. And the truth is, If I'm anything at all, I'm the one getting scammed because I don't know if it works.

So anyway, I took the plunge and ordered this glop from over seas and as I recall it was about $55 for about a 6 week supply. I'm fine with that because $55 for hope seems like a pretty good deal.  Now what this stem cell hair loss cream does is activate the Stem Cells present in your scalp to promote hair growth and thickness.  Also it is supposed to help change the grey hair back to its original natural color.

Now if all goes well I'm a perfect candidate for this type of treatment because I have hair. Most of my follicles seem to have very thin hairs remaining in them so it's not like my follicles aren't producing anything. One cool thing is that my beard recently starting going grey. It's been about 6 months since I noticed and there happens to be about a half inch section on the right of my chin that has turned pure white. It looks weird because it is the only concentrated section of white any where on my body. So the good news I mentioned is that I'm gonna smear this gook on my head and on that white part of my beard and see if it starts to change the color over time. I've always heard that facial hair acts exactly opposite of scalp hair but I might as well give this a test.

I will say that I've only been on the stem cell hair loss cream for 2 days so there will be no effect yet. It was supposed to take 10 days to arrive by mail but it took 28, I was thinking I got taken but at least the goo arrived and I have it in my hands. Whether it makes any improvement in my hair only time will tell. I would like to point out that I have high hopes for the stem cell hair loss cream and very low expectations because if it worked, then I imagine we would all be hearing about it.  I will keep you posted and feel free to comment below

The Oprah Effect and Hair Transplants

The Oprah Effect on CNBC



After watching the Oprah Effect on CNBC the other night I was amazed how a simple mention by Oprah Winfrey can launch a product or even in industry into a total transformation.

This can be seen with all those "as seen on Oprah" sales pitches you get in your email inboxes. A perfect example is her buddy Dr. Oz endorsing Resveratrol as an age defying pill. Resveratrol sales are through the roof, and there are studies showing Resveratrol reverses hair loss.

On today's show, Dr Oz was at again and brought out Hair Transplant Surgeon Dr Bernstein. They showed a clip about FUE hair transplants and suggested that todays results look completely natural. The hair transplant result was shown live by a member of the audience and Oprah couldn't tell the difference.

This is a great endorsement for Hair Transplants and perhaps the Oprah Effect will remove some of the stigma involved with Hair Restoration.

Dr Bernstein did mention that Propecia and Rogaine should be tried first, but Hair Transplants are a viable solution for men and their hair loss.

New Breakthrough Baldness Treatment

Baldness Treatment

Look being bald or going bald or baldness itself is not a big deal for some people but it is for me. So every time there is news of a baldness cure I have to take a careful look.

I will admit that ever since I started doing research online about hair loss, I have found several baldness treatments I was ignoring and together they have yielded some hair growth. So I do believe there is some help out there.

I've been monitoring the chat in the hair loss forums about Dr Robert Jones Platelet Rich Plasma therapy for thinning hair and today Dr Jones published a video explaining this breakthrough Baldness Treatment.

Whenever, we hear about advancements in hair loss treatments they always seem to be about mice and years away from human study, but Dr Jones is treating hair loss patients with Platelet Rich Plasma Therapy in his office already so I was very intrigued about his video.

Baldness: Resveratrol & Curcumin Grow Hair

I have been taking resveratrol for hair loss for months and I've noticed great things about my skin but not so much my hair growth. I remembered seeing the 60 minutes story featuring resveratrol and remembered that it needed to be mixed with Curcumin to help stop hair loss.

Here is the study regarding Resveratrol and Curcumin for Hair loss. It is everywhere online but I wanted to post it for my readers. I have researched the best Resveratrol and Curcumin to buy because every one and their mother is selling watered down versions of resvertrol which don't even seem to come from the right natural source.

I'm not selling anything on this site so if you want to know what I use and how I get it at a reduced cost through smart shopping, just leave me a comment. I really just want people to get hair loss and hair loss remedy info on my blog. Not sales, sales, sales!

PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD

The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.

Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds.

Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.

Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.

The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too.

Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).

According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.

According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.

In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg.

The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.

Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.

Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.

The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.

In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing.

MATERIALS AND METHODS

The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.

Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared. Case 6: 64 years old man affected by prostratitis that tried various treatments. After the treatment with Capsures, 6 capsules a day, after 30 days had no more perineal pain and had a hair growth.

Case 14: 75 years old man, operated 4 years before for radical prostatectomy, intolerant to hormonal treatment he has been treated with Capsures, 4 pills a day for 60 days. His PSA value reduced from 4.5 to 2.4.

As far as its action on hair is concerned, some patients, especially women that were considerably loosing their hair, after 20 days of treatment confirmed to have had a reduction in their hair loss. In bald patients, the hair, sometimes of the original color restarted to grow even after the ablation of the white hair.

CONSIDERATIONS AND CONCLUSIONS

The compound containing just resveratrol as active agent (Resverage) didn't cause a reduction of the PSA value and this can be due to the low bioavailability of the molecule. In the cases of prostate carcinoma the efficacy of the association of resveratrol with curcumin can be due to a higher concentration in the circulation and therefore in the tissues explained by the lipophilia of the active elements of curcumin.

The association of resveratrol and curcumin seems to have a synergic effect that enhances the anti-inflammatory power of the two active elements. It is an essential activity because in the prostate carcinoma there is a phlogistic action caused by hyperincretion of enzymes as the cyclooxygenase 1 and 2.

As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances.

Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.

Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.

The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.

Do You Believe Lasers Will Stop Hair Loss

There is FDA approval for lasers to help stimulate hair growth but most experts agree it's no miracle. I have a hair max laser comb and I would say it's bunk, but we all want hair. So if you want to get one, or any of the new lasers, I would buy them used on e-bay

clipped from www.hair-loss-cause.com A New Technique: Laser Hair Loss Treatment One type of laser hair loss treatment is the laser comb, which is a device that can be used by the individual in the comfort of his own home. The way the device works is that phototherapy is administered by combing the person’s hair with the device so that the hair follicles are stimulated in addition to the topical solutions that the individual might be using. These laser combs are often the best laser hair loss treatment to use after having a hair replacement surgery to promote the healing of the different hair transplants in the scalp. The combs are usually used in addition to the treatments that are done in the doctor’s office as a way to enhance the hair recovery.