Prostaglandin D2 (or PGD2) is a prostaglandin that is central to development of dermatologic inflammation, pattern hair loss, and allergic disorders, such as asthma.
A newly released, 2012 study showed a cause and effect relationship between abnormally high levels of PGD2 and male pattern baldness. With topical application they found PGD2 prevents hair growth, and mice who were genetically predisposed to produce higher levels of PGD2 had diminished hair growth. They additionally discovered PGD2 levels were much elevated in balding scalp versus non-balding scalp tissue. The study concluded that one of the receptors involved in production of PGD2, GPR44, constituted a precise therapeutic target for hormonal hair loss in both men and women.
Sci Transl Med. 2012 Mar 21; 4(126):126ra34.
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G.
Source
Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Abstract
Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D(2) synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA. The product of PTGDS enzyme activity, prostaglandin D(2) (PGD(2)), is similarly elevated in bald scalp. During normal follicle cycling in mice, Ptgds and PGD(2) levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD(2) inhibits hair growth in explanted human hair follicles and when applied topically to mice. Hair growth inhibition requires the PGD(2) receptor G protein (heterotrimeric guanine nucleotide)-coupled receptor 44 (GPR44), but not the PGD(2) receptor 1 (PTGDR). Furthermore, we find that a transgenic mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2 expression to the skin, demonstrates elevated levels of PGD(2) in the skin and develops alopecia, follicular miniaturization, and sebaceous gland hyperplasia, which are all hallmarks of human AGA. These results define PGD(2) as an inhibitor of hair growth in AGA and suggest the PGD(2)-GPR44 pathway as a potential target for treatment.
Because PGD2's correlation with asthma is well established, several drugs that down regulate PGD2 are already in clinical trials. PGD2 inhibitors would serve to promote hair growth. Scientists involved in this study, including Dr. Cotsarelis of stem cell research renown, state that they've already formulated pills containing the vital PGD2 blocking properties. But why wait for an expensive, patented medication. Resveratrol has been shown to significantly suppress PGD2 at low concentrations readily obtainable through oral dosing, as evidenced by the abstract presented below. Oral resveratrol has also been shown to have anti-asthmatic effects superior to that of dexamethasone, the side effect wrought, cortico-steroid of choice for managing asthma symptoms.
Planta Med. 2004 Apr;70(4):305-9.
Resveratrol inhibits the release of mediators from bone marrow-derived mouse mast cells in vitro.
Baolin L, Inami Y, Tanaka H, Inagaki N, Iinuma M, Nagai H.
Source
Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, P. R. China.
Abstract
Resveratrol is a natural phytoalexin occurring in grapes, vines and peanuts and possesses both antitumor and antioxidation capabilities. Its chemoprotective actions are attributed partially to its anti-inflammation effect. The present study is aimed at checking the inhibitory actions of resveratrol on the release of mediators from bone marrow-derived mouse mast cells (BMMC) in vitro. Mast cells were prepared by isolating bone marrow cells from intact mice femora and culturing them for 4 weeks in the presence of IL-3 and FCS. The release reaction was triggered by IgE or calcium ionophore (A23187). Mediated by IgE, the release of histamine and tumor necrosis factor-alpha was significantly inhibited by resveratrol at a concentration of 100 microM; IgE-mediated release of leukotrienes and prostaglandin D (2) was also strongly suppressed at concentrations of 100 and 10 microM.Also, A23187-mediated release of histamine and leukotrienes release was strongly reduced by resveratrol at concentrations of 100 and 10 microM, respectively. Resveratrol exhibited its behavior without a significant cytotoxic activity against mast cells. In conclusion, resveratrol is a potent non-selective inhibitor of mediator release from activated mast cells and deserves further investigation of its biological modulations.
The ideal dose of Resveratrol has been a subject of debate for some time. The scientific community is coming to some agreement, that a dose between 200-300 mg optimizes health benefits for human use. Recent research in Italy revealed Resveratrol is particularly effective at stimulating hair growth when combined with Curcumin.
Get $5 off Resveratrol Or Any Product at http://www.iherb.com/mypage/Reviewer1669246
Showing posts with label hair loss. Show all posts
Showing posts with label hair loss. Show all posts
Wednesday, July 11, 2012
Saturday, April 21, 2012
Possible New Hair Loss Cure
"Triarco”, a Bio-Tech company based in New Jersey, released some very intriguing results of a pilot study for their patented prostate product Alphastat®, which inhibits 5-alpha reductase. The three-month study on male patients ages 55-68 reported a 40% decrease in blood levels of DHT, which has some obvious implications for treating hair loss.
In addition to improved Urogenital symptoms, there were, unlike Proscar and Avodart, reports of increased, not decreaesd sexual function.
As you know, pharmaceutical 5 alpha reductase inhibitors prevent balding and promote hair growth by lowering serum DHT. The documented side effects of pharmaceutical 5 alpha reductase inhibitors include sexual dysfunction, reduced libido, and depression. There were evidently no reports of any negative side effects in this study.
Triarco stated “We are very pleased with the results of this clinical study because it confirms the results of the pre-clinical studies and is, to our knowledge, the first natural product shown to lower PSA and serum DHT levels in humans."
If you follow our updates you may already know that consumption of Soy Isoflavones, particularly with Black and Green Tea Extracts, lowers serum DHT as well.
In addition to its effects on reducing serum DHT, Alphastat also raises testosterone, and lowers estradiol. Alphastat is a combination of the caratenoid Astaxanthin and Saw Palmetto Extract.
Study Summation
The investigators gave 40 healthy male subjects between the ages 40 and 70, 800 mg or 2g of Alphastat, for two weeks. Below you can evaluate the effect of both dosages on the concentration of serum testosterone in the blood of the test subjects.
More importantly for hair growth, both dosages rapidly reduced serum DHT, as noted below.
Estradiol level was reduced as well, with the smaller dose being slightly more effective than the larger dose (see below).
The study appears to be scientifically valid, with a sufficient sample size of 42 males, measurable blood tests, and sound statistical methodology. It was published in a peer-reviewed scientific journal. This means that at least two independent researchers have reviewed the article and deemed it to be fit for publication
Comment
There is no evidence suggesting Saw Palmetto per se, has any effect whatsoever on Testosterone levels or serum DHT levels (Saw Palmetto *does* moderately inhibit DHT binding to receptors). The desirable effects on hormone blood levels produced in this study are due to Astaxanthin.
Astaxanthin is also documented to reduce bodyfat, increase stamina, and maintain glycogen stores in animal models.
Dissecting Alphastat Ingredients
Alphastat® is comprised of 200 mg of a “patented complex” of Saw Palmetto Extract extract and Haematococcus pluvialis algae extract, providing free fatty acids and Astaxanthin.
Saw Palmetto Extract is typically used at about 300 mg, so it is likely that most of this complex is Saw Palmetto Extract.
Astaxanthin is a relatively expensive supplement and is generally available in 2 to 4 mg capsules.
Given the listed ingredients, this “patented complex” is likely about 200 mg Saw Palmetto Extract, and about 2-4 mg Astaxanthin.
Alphastat also includes 15 mg of zinc monomethionine (OptiZinc) which is a known inhibitor of aromatase.
Alphastat at a higher dose for a fraction of the price
By utilizing three separate products: “Super Saw Palmetto Extract”, “Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G” and OptiZinc , one can have the benefits of Alphastat for a fraction of the cost, with larger amounts of each ingredient.
Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G is a combination of caratenoids that in addition to providing 6 mg of Astaxanthin, provides 38 mg of Lutein, 3.75 mg of Meso-Zeaxanthin, and 2.2 mg of C3G ( European) Black Currant Extract. These additional ingredients, in combination with Astaxanthin, prevent against age related vision loss, macular degeneration, and function as an internal UV protectant to damage to skin caused by ultra-violet light, while simultaneously promoting tanning. In addition to raising testosterone, lowering DHT, and estrogen, it markedly reduces the production of wrinkle- and sag-inducing skin enzymes.
Both "Super Saw Palmetto” and the multi-component “Ultra Natural Prostate Formula” are rich in bioactive, high-molecular weight compounds including beta-sitosterol, which has been shown to interfere with peripheral DHT receptor binding activity.
DeepExtract™ used in both Super Saw Palmetto and the Ultra Natural Prostate Formula, is a patented, ultra-high pressure CO2 technology engineered to recover far greater amounts of bioactive, high-molecular weight fatty acids from the saw palmetto berry during the extraction process. The result is a superior formula containing key ingredients in higher concentrations than other commercially available extracts. DeepExtract™ ensures the most desirable and complete bioactive extract profile available.
Optizinc is the most bio-available form of Zinc. Zinc has been used as a standalone treatment for acne, which like balding, is an androgen mediated disorder. Like Astaxanthin, it also has an aromatase inhibiting property as well.
By using Alphastat, or by combining the three aforementioned ingredients, one can effectively lower DHT, inhibit its binding to receptors, raise testosterone and reduce estradiol, which has significantly positive implications for prostate health, skin aging, vision protection, and of course, hair loss.
New Recommended Treatment Compound:
Super Zeaxanthin with Lutein, Meso-Zeaxanthin Plus Astaxanthin and C3G
Monday, April 20, 2009
Rupert Everett's Great Hair Transplants
I have been noticing Rupert Everett lately because he was having obvious hair transplants. So this article popped up today on yahoo about men and plastic surgery which featured Rupert Everett. I was surprised they noticed every possible procedure this guy had but nobody mentioned his hair loss and hair transplants. I think his hair looks great!
We’ve always thought Rupert Everett was dreamy, particularly in “My Best Friend’s Wedding.” All the more reason why we were horrified upon finding this recent photo of him from his appearance on “The Martha Stewart Show.”
The picture on the left is just one year old. The photo on the right is from last week. Shocking!
The actor, currently starring in Blithe Spirit on Broadway, has obviously had a great deal of work done. Dr. Brian S. Glatt, founder of the Premier Plastic Surgery Center of New Jersey, thinks the 49-year-old actor had a facelift. “His cheeks are fuller and lifted, and his jawline and neck are pulled back and smoother,” says Dr. Glatt. His forehead is the work of Botox. “I think he’s definitely using it. He is very animated, and there are no lines visible on his forehead.”
But that’s not all—Dr. Glatt believes he also got a chin implant! “The shape and projection of the chin is drastically different. It’s much more pointed,” he says, estimating the combined surgeries to have cost around $25,000.
“This is an impressive difference,” says Dr. Glatt. “He looks 10 years younger!” Um, no, he looks like a scary robot! A little botox is maybe one thing, but our beloved Everett is totally unrecognizable! In fact, he looks kind of like Bruce Jenner, another awful surgery victim.
We can’t help but notice a surge in plastic faces amongst Hollywood men like John Travolta, Ray Liotta and Mickey Rourke. Nicholas Cage’s hair plugs also make us shudder. Why not go the route of Bruce Willis and shave it all off and make that your look? No one thinks you miraculously grew hair after balding for 20 years. The plugs are worse than a bad toupee.
Do you think it’s somehow worse when men receive cosmetic procedures?
Star
The picture on the left is just one year old. The photo on the right is from last week. Shocking!
The actor, currently starring in Blithe Spirit on Broadway, has obviously had a great deal of work done. Dr. Brian S. Glatt, founder of the Premier Plastic Surgery Center of New Jersey, thinks the 49-year-old actor had a facelift. “His cheeks are fuller and lifted, and his jawline and neck are pulled back and smoother,” says Dr. Glatt. His forehead is the work of Botox. “I think he’s definitely using it. He is very animated, and there are no lines visible on his forehead.”
But that’s not all—Dr. Glatt believes he also got a chin implant! “The shape and projection of the chin is drastically different. It’s much more pointed,” he says, estimating the combined surgeries to have cost around $25,000.
“This is an impressive difference,” says Dr. Glatt. “He looks 10 years younger!” Um, no, he looks like a scary robot! A little botox is maybe one thing, but our beloved Everett is totally unrecognizable! In fact, he looks kind of like Bruce Jenner, another awful surgery victim.
We can’t help but notice a surge in plastic faces amongst Hollywood men like John Travolta, Ray Liotta and Mickey Rourke. Nicholas Cage’s hair plugs also make us shudder. Why not go the route of Bruce Willis and shave it all off and make that your look? No one thinks you miraculously grew hair after balding for 20 years. The plugs are worse than a bad toupee.
Do you think it’s somehow worse when men receive cosmetic procedures?
Sunday, April 19, 2009
Hair Loss Remedy?
I think this stuff is probably a load of junk but I do like the green tea which I take orally for hair loss. It sounds good but nobody that I know is talking about it.
So take a look below and BUYER BE WARE. I'm not endorsing this so there is no link to their trial. If you really want this product, just google it.
The Smart System is one of the hottest new programs in America
So take a look below and BUYER BE WARE. I'm not endorsing this so there is no link to their trial. If you really want this product, just google it.
 |  |
|
 | Smart is an Organic Product Smart is an organic product that is proven to stop hair loss and re-grow hair. Independent, blind, double blind and placebo controlled studies have proven that Smart stops hair loss and re grows hair in over 91.2% of its users. |
| Apple Polyphenols An apple a day, keeps the doctor away. But an apple a day also keeps DHT and Hair loss away and helps nourish the scalps and hair follicles to grow strong healthy new hair! Independent scientific studies conducted in Japan have found concrete medical evidence that Apple Polyphenols (extracted from the apple fruit) increase hair growth by over 300%. |
| Rooibos (Red tea) Rooibos is a Rare and Exotic African red tea which contains 37 unique antioxidant substances and is rich in minerals, calcium and potassium. |
| Green Tea According to a leading American research firm, Green Tea’s amazing antioxidant properties are tested and proven to stops hair loss. The tests conclude when Green Tea is applied directly to the scalp, it acts as an Anti-inflammatory agent that stops hair loss in both men and women at an overwhelming rate of 97%. |
 | The Kit Includes: |  |
Scientifically TESTED and PROVEN to work in just 2 Weeks
Is it true, can it really be this easy to have a shiny, beautiful, full head of hair?
Find out for yourself how Ordinary People across the country have noticed a dramatic change in their appearance!
Try it absolutely FREE of Risk!
The Smart System is one of the hottest new programs in America
Hair Transplants By Bosley
I never like to endorse one hair transplant surgeon over another but every one out there has there own opinions, success stories, and disasters. So please comment about Bosley if you can add to the conversation.
At Bosley, the surgical transplantation of hair follicles is a remarkably simple outpatient procedure.
Lifelong hair follicles are found in good supply in virtually all men, even men with advanced baldness. These lifelong hairs are concentrated in an area at the back and sides of the head. We call this region the “donor area.” During the hair transplant procedure, our physicians take excess hairs - follicles and all - from this plentiful area and relocate them to areas of thinning and balding on the top or front of the head.
The extreme close-up photographs below are of Bosley patient hairlines which were created on balding scalp.
Of course your approval of our strategy for your hair is an absolute must and will be your doctor's central guide in tailoring your new hairline. Please be advised that individual hair transplant results may vary.
Why hair transplantation works
The medical process for hair restoration involves the transplanting of hairs and follicles from one area of the head to another.
Every single follicle of hair on the human scalp is genetically programmed before birth to either become sensitive to the male hormones which begin to appear during puberty - causing the follicle to wither and die in time - or not to become sensitive to these hormones and continue growing throughout one's lifetime.
During the hair transplant procedure, grafts are placed ONE AT A TIME in the thinning and balding areas. Bosley physicians are trained to artistically perform this procedure in a manner that results in virtually undetectable natural-looking restored hairlines and natural density.
Transplantation Process
At Bosley, the surgical transplantation of hair follicles is a remarkably simple outpatient procedure.
Pursuing the Perfect Transplanted Hairline:
The scientific and artistic techniques that Bosley has been perfecting since 1974 allow Bosley physicians to recreate soft, natural, living hairlines that are virtually indistinguishable from the original hairlines that have eroded away. Finished Bosley hairlines are usually so soft and natural, they don't have to be hidden by hair combed over in the front.
The Procedure:
During the hair transplant procedure, grafts are placed ONE AT A TIME in the thinning and balding areas. Bosley physicians are trained to artistically perform this procedure in a manner that results in virtually undetectable natural-looking restored hairlines and natural density.
For Men and Women:
The techniques and process utilized at Bosley are equally effective in treating hair loss for both men and women.
How Propecia Works
I'm not a big fan of Propecia because I think avodart is better. However, getting a script for Avodart is not easy so let's take a look at How Propecia works
How PROPECIA Works
Reduces DHTa, a key cause of hair loss
PROPECIA significantly reduces DHT, a key cause of hair loss, by inhibiting the formation of DHT in your scalp.
Lowering DHT appears to inhibit the further shrinking of affected hair follicles.
DHT is a substance in the body that can shrink the hair follicle until it no longer produces visible hair. Scientists believe DHT and family history are key factors in hair loss. Learn more about the causes of male pattern hair loss.
aDHT=dihydrotesterone.
PROPECIA blocks the formation of DHT and, in this way, appears to interrupt the development of male pattern hair loss.
PROPECIA helps reduce further hair loss and regrow visible hair.
PROPECIA is the first and only FDA-approved pill proven to treat male pattern hair loss on the vertex (top of head) and anterior mid-scalp area (middle front of head) in men.
Important Information About PROPECIA
PROPECIA was developed to treat mild to moderate male pattern hair loss on the vertex (top of head) and anterior mid-scalp area (middle front of head) in MEN ONLY. There is not sufficient evidence that PROPECIA works for receding hairlines at the temples.
PROPECIA is for the treatment of male pattern hair loss in MEN ONLY and should NOT be used by women or children.
Women who are or may potentially be pregnant must not use PROPECIA and should not handle crushed or broken PROPECIA tablets because the active ingredient may cause abnormalities of a male baby’s sex organs. If a woman who is pregnant comes into contact with the active ingredient in PROPECIA, a doctor should be consulted. PROPECIA tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed.
In clinical studies for PROPECIA, a small number of men experienced certain sexual side effects, such as less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen. Each of these side effects occurred in less than 2% of men and went away in men who stopped taking PROPECIA because of them.
You may need to take PROPECIA daily for 3 months or more before you see a benefit from taking PROPECIA. If PROPECIA has not worked for you within 12 months, further treatment is unlikely to be of benefit.
PROPECIA can only work over the long term if you continue taking it. If you stop taking PROPECIA, you will likely lose any hair you have gained within 12 months of stopping treatment.
Although results will vary, generally you will not be able to grow back all the hair you have lost.
Saturday, April 18, 2009
Resveratrol and Curcumin For Hairloss
All the news about Resveratrol and hair loss has gotten me pretty excited but as always when it comes to growing hair and baldness cures I have high hope and low expectations.
I will say that in a lot of these hair loss forums there's a lot of buzz about how Curcumin enhances the effects of Resveratrol so of course, I'm getting in on this one.
About 2 months ago went to the health food store and bought some curcumin and a bottle of resveratrol but I didn't really know what I was doing.
So after a bit of research I've gotten some of what is considered the best of the best and gone with
Jarrow Formulas Resveratrol 100 and take Life Extension Super Bio-Curcumin
Now this is just part of my regiment that is producing those exicting little buds of new hair growth but I'm going to take this stuff until the science says its bunk.
By the way, the links above are about 40% cheaper than buying it at a store. If you include the following promo code LAT159 , you will recieve $5 of your order and accumulate credit for each purchase you make from I-herb
Taking supplements can get expensive so finding a place to buy vitamins online is great.
I will say that in a lot of these hair loss forums there's a lot of buzz about how Curcumin enhances the effects of Resveratrol so of course, I'm getting in on this one.
About 2 months ago went to the health food store and bought some curcumin and a bottle of resveratrol but I didn't really know what I was doing.
So after a bit of research I've gotten some of what is considered the best of the best and gone with
Jarrow Formulas Resveratrol 100 and take Life Extension Super Bio-Curcumin
Now this is just part of my regiment that is producing those exicting little buds of new hair growth but I'm going to take this stuff until the science says its bunk.
By the way, the links above are about 40% cheaper than buying it at a store. If you include the following promo code LAT159 , you will recieve $5 of your order and accumulate credit for each purchase you make from I-herb
Taking supplements can get expensive so finding a place to buy vitamins online is great.
Sunday, April 12, 2009
Rogaine on Steroid to Stop Hair Loss
Minoxidil and Hair Growth
You know years ago I glopped a bunch of Rogaine on my head to try and grow some peach fuzz on the top of my head because the FDA said I could.
Now anyone suffering from male pattern baldness or female hair loss isn't looking for peach fuzz. We want hair and Rogaine typically was not the answer.
However, these days, every doctor and mad scientist is screwing around with minoxidil to make it better, faster and stronger and some of these brews will help you stop hair from falling out.
Which Minoxidil Formula Will Work Best?
Using Minoxidil topically to grow hair was discovered by chance. Minoxidil was originally developed to treat hypertension, but patients taking Minoxidil started growing unwanted hair. This side effect led to the testing of using topical Minoxidil to grow hair on balding sites.
Both males and females may use generic Minoxidil. Generic Minoxidil comes in two concentrations, mainly 2% and 5%. It is recommended that males use Generic Minoxidil 5% whilst females use Generic Minoxidil 2%.
Minoxidil works best on the crown. Why Minoxidil works remains a mystery. Generic Minoxidil is a vasodilator and may increase the blood supply to the follicles. Minoxidil has to be applied twice a day to the affected area for at lest six months. Since it is applied locally, Generic Minoxidil is relatively safe as negligible amounts are absorbed in the bloodstream.
There are now so many variations of Minoxidil out there that choosing the right one is nearly impossible because everyone is trying to sell you something. The important part is to use one of them because even though it will probably not help grow your hair back it will slow the hairloss down.
I try to keep it simple: I use Rogaine 5% because it is readily available and inexpensive. Then I put a few drops of rosemary oil and liquid saw palmetto extract in as well. Rosemary has long been associated with hair health and saw palmetto is a natural DHT blocker used by many hair loss sufferers. All of these items can be found at
You know years ago I glopped a bunch of Rogaine on my head to try and grow some peach fuzz on the top of my head because the FDA said I could.
Now anyone suffering from male pattern baldness or female hair loss isn't looking for peach fuzz. We want hair and Rogaine typically was not the answer.
However, these days, every doctor and mad scientist is screwing around with minoxidil to make it better, faster and stronger and some of these brews will help you stop hair from falling out.
Which Minoxidil Formula Will Work Best?
Using Minoxidil topically to grow hair was discovered by chance. Minoxidil was originally developed to treat hypertension, but patients taking Minoxidil started growing unwanted hair. This side effect led to the testing of using topical Minoxidil to grow hair on balding sites.
Both males and females may use generic Minoxidil. Generic Minoxidil comes in two concentrations, mainly 2% and 5%. It is recommended that males use Generic Minoxidil 5% whilst females use Generic Minoxidil 2%.
Minoxidil works best on the crown. Why Minoxidil works remains a mystery. Generic Minoxidil is a vasodilator and may increase the blood supply to the follicles. Minoxidil has to be applied twice a day to the affected area for at lest six months. Since it is applied locally, Generic Minoxidil is relatively safe as negligible amounts are absorbed in the bloodstream.
There are now so many variations of Minoxidil out there that choosing the right one is nearly impossible because everyone is trying to sell you something. The important part is to use one of them because even though it will probably not help grow your hair back it will slow the hairloss down.
I try to keep it simple: I use Rogaine 5% because it is readily available and inexpensive. Then I put a few drops of rosemary oil and liquid saw palmetto extract in as well. Rosemary has long been associated with hair health and saw palmetto is a natural DHT blocker used by many hair loss sufferers. All of these items can be found at
Saturday, April 11, 2009
Dutasteride Really Does Work to Stop Hairloss
Stop Your Hair Loss
Dutasteride is the active ingredient in Avodart which is used in the treatment for an enlarged prostate. It blocks DHT which is a major factor in Male Pattern Baldness. It is not prescribed for hair loss but if you are a hairloss freak like me you may want to get a hold of some.
Now, since it is a prescription drug I am not going to tell you where to get it without a perscription. I get it and I use it. I have had no side effects whatesover and I will continue to use it forever or until something better comes along. I'm sorry I cannot help you contact the Dustasteride Discount Pharmacy but if there are no advertisers selling discount generic dutas, proprecia and proscar from discount pharmacies on other pages, just leave a comment and I will help you out if I can. send you to an
Contact the Dutasteride Discount Pharmacyoff shore pharmacy that will sell it to you without a perscription but if you are smart you will be able to find some on this page. I'm sure there are ads for it somehwere.Before you deside to self diagnose your hairloss problems, please now that propecia does work a little bit. It laymens terms it stops one type of DHT from forming and that helps allot with keeping your hear.
Dutasteride, dutas, avodart and generic avodart inhibits two types of DHT from effecting the scalp so it is better. It will probably be approved by the FDA in some form or another down the road but it is used all over the world to treat hair loss.
Again, if you search hair loss forums around the web you will find stories from hundreds of men using dutas for mail pattern baldness and very few will report bad side effects.
So let's learn a little more about Dutasteride
Dutasteride (marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) is a 5-alpha-reductase inhibitor5-alpha-reductase inhibitor, a drug which inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used to treat conditions caused by DHT, such as benign prostatic hyperplasia (BPH). Avodart is manufactured and marketed by GlaxoSmithKline.
Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group. Dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only one. But a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice.
The most common adverse reactions reported in subjects receiving AVODART were impotence, decreased libido, breast disorders (including "Gynecomastia" Ejaculation disorders. Study withdrawal due to adverse reactions occurred in 4% of subjects receiving AVODART and 3% of subjects receiving placebo. The most common adverse reaction leading to study withdrawal was impotence (1%).This claim needs references to reliable sources since September 2008
Resveratrol and Hairloss
Resveratrol is one of the most exciting anti aging discoveries in year.
Can Resveratrol help grow your hair back?
You may be surprised to find out the answer is yes. The key is to combine the resveratrol with another natural supplement called curcumin. If you are interested in the science behind the discovery please keep reading. Or, just scroll to the bottom and find out how to get your hands on it.
First, Lets Watch the Resveratrol Video Seen on 60 minutes and pay attention to the small mention of how it may work to increase hair growth. Then read the study and see how adding a few other over the counter ingredients to make it work for you.
Then, get the stuff mentioned in the video wholesale and a further $5 discount for first time orders using coupon code LAT159 at Checkout.
So Enjoy your Optimized Resveratrol And Super Bio Curcumin
Here is an exciting new Study with complete instruction on how you can get your hands on Resveratrol for Hair loss today.
Italian Patent Details Hair Growth Effects of Resveratrol/Curcumin Combination
So what does this mean for hair loss suffers?
The long and short of it is that because these ingredients are not monitored by the FDA we can go ahead and take them and help to reverse hair loss. The supplements can be found in many health food stores but I find they are very expensive. Purchasing them online will save about 50% and I have a coupon code which will save an extra $5 for anyone looking to try out the Resvertrol and Curcumin together.
The ingredients from the study above can be found here: To save $5 enter the following code at checkout. LAT159
Now for some even better news. When you purchase the supplements from I-herb you will get your own promo code and you will save more money with any purchase. I find that any vitamin or natural product I find in health food stores average at least %48 cheaper online.
Enjoy your Optimized Resveratrol And Super Bio Curcumin and don't forget to save $5 by entering LAT159 at checkout
Can Resveratrol help grow your hair back?
You may be surprised to find out the answer is yes. The key is to combine the resveratrol with another natural supplement called curcumin. If you are interested in the science behind the discovery please keep reading. Or, just scroll to the bottom and find out how to get your hands on it.
First, Lets Watch the Resveratrol Video Seen on 60 minutes and pay attention to the small mention of how it may work to increase hair growth. Then read the study and see how adding a few other over the counter ingredients to make it work for you.
Then, get the stuff mentioned in the video wholesale and a further $5 discount for first time orders using coupon code LAT159 at Checkout.
So Enjoy your Optimized Resveratrol And Super Bio Curcumin
So Now on to Resveratrol and Hair Loss
Here is an exciting new Study with complete instruction on how you can get your hands on Resveratrol for Hair loss today.
A patent from Italy claims hair growth stimulation and other anti-aging effects from an oral combination of Resveratrol and Curcumin.
Given Resveratrol’s multiple mechanisms of action in regards to longevity, inflammation, cardiovascular health, aromatase inhibition, and cancer treatment/prevention, and the established ability of Curcumin to inhibit TGF-B, (an inflammatory cytokine inexorably associated with balding), this comes as no great surprise.
Of additional interest is Curcumin’s apparent stimulatory effects on Substance P. Here are some excerpts from the patent itself.
PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND RESVERATROL AND USES THEREOF IN MEDICAL FIELD
The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.
Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds.
Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.
Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.
The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too.
Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).
According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.
According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.
In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg.
The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.
Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.
Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.
The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.
In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing.
MATERIALS AND METHODS
The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.
Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared. Case 6: 64 years old man affected by prostratitis that tried various treatments. After the treatment with Capsures, 6 capsules a day, after 30 days had no more perineal pain and had a hair growth.
Case 14: 75 years old man, operated 4 years before for radical prostatectomy, intolerant to hormonal treatment he has been treated with Capsures, 4 pills a day for 60 days. His PSA value reduced from 4.5 to 2.4.
As far as its action on hair is concerned, some patients, especially women that were considerably loosing their hair, after 20 days of treatment confirmed to have had a reduction in their hair loss. In bald patients, the hair, sometimes of the original color restarted to grow even after the ablation of the white hair.
CONSIDERATIONS AND CONCLUSIONS
The compound containing just resveratrol as active agent (Resverage) didn't cause a reduction of the PSA value and this can be due to the low bioavailability of the molecule. In the cases of prostate carcinoma the efficacy of the association of resveratrol with curcumin can be due to a higher concentration in the circulation and therefore in the tissues explained by the lipophilia of the active elements of curcumin.
The association of resveratrol and curcumin seems to have a synergic effect that enhances the anti-inflammatory power of the two active elements. It is an essential activity because in the prostate carcinoma there is a phlogistic action caused by hyperincretion of enzymes as the cyclooxygenase 1 and 2.
As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances.
Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.
Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.
The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.
Editor’s Comment- It would appear that based upon the data presented here , that a Curcumin/Resveratrol combo would be well worth integrating into one’s treatment regime. The beauty of the patent registry is that allows you to access usable information years ahead of commercial availability. In this case you don’t have to wait for “Capsures” to hit the market. You can easily put together and use a much higher dose and bio-available combination of Resveratrol and Curcumin at a fraction of the cost.
Given Resveratrol’s multiple mechanisms of action in regards to longevity, inflammation, cardiovascular health, aromatase inhibition, and cancer treatment/prevention, and the established ability of Curcumin to inhibit TGF-B, (an inflammatory cytokine inexorably associated with balding), this comes as no great surprise.
Of additional interest is Curcumin’s apparent stimulatory effects on Substance P. Here are some excerpts from the patent itself.
The present invention deals with a pharmaceutical composition comprising curcumin and resveratrol and uses thereof in medical field. More specifically, the composition object of the invention can be advantageously employed for retarding ageing, for the prevention of vascular diseases, for the treatment and prevention of cancers as, for example, prostate carcinoma, skin diseases as psoriasis, and diseases of the piliferous system as hair loss.
Resveratrol is a polyphenol present in grapes, especially in its peel and in its seeds.
Curcumin is an extract of the root of the Curcumea Longa, a plant well known since a long time for its pharmaceutical properties. Nowadays curcumin is well known for its power of reducing cholesterol, its diuretic, choleretic, anti-inflammatory ability and for ameliorating the general conditions of patients treated with chemotherapy for neoplasia.
Particular feature of Curcumin is to belong to the capsaicinoids family, substances characterized by a pungent taste, similar to the one of pepper. From a point of view of molecular biology, the presence of a vanilloid receptor on the cell membrane and close to the mitochondrial structures can explain the induction of apoptosis or planned death of cells that would have become neoplastic. Moreover, in the Central Nervous System there are various receptors of capsaicinoids and this could explain the enhancement of the anti-aging action of resveratrol by curcumin.
The group of patients that has assumed only resveratrol didn't show any modification on the PSA, while the group treated with resveratrol and curcumin showed with great surprise a reduction, sometimes also relevant, in variable time periods. Moreover, during this testing, the patients treated with resveratrol and curcumin surprisingly showed positive improvements in the treatment of psoriasis and the attenuation and even a stop of the hair loss, a reduction of the hair graying and the rebirth of hair in bald areas sometimes even of the original color too.
Regarding its action on hair growth, even if not yet known, it is probably linked to the release of P substance. The growth and the pigmentation of the hair follicle would depend on mesenchymal-epithelium-neiroderic interactions not very well-known yet, where the P substance would stimulate the hair growth in vivo (RaIf Paus et al Investigation Labs, VoI 71, No 1 , p.135, 1994).
According to the invention, the pharmaceutical composition can comprise also vitamin E and/or wheat germs containing vitamin E. In fact, the powdered wheat germs are one of the richest natural resources of vitamin E (or tocopherol) and are one of the most effective antioxidants against free radicals, the aggressive substances that proliferate in our body because of the action of pollution, inaccurate diets, sun or just age.
According to another embodiment of the present invention, the pharmaceutical composition can also comprise Capsaicin and/or the fruit of capsicum annum, which contains capsaicin. Capsicum annum, its powdered fruit in particular, is rich in important nutritional substances as flavonoids, vitamins (C, E, PP, and K), lecithins, mineral salts and capsaicin, an alkaloid responsible for its particular taste and for its activating properties. The extract of capsicum seems to be very effective in stimulating the vitality of the tissues and in activating the venous and capillary circulation.
In particular, in the composition according to this invention, the content of resveratrol can range from 3 to 6 mg; of Curcumin from 15 to 30 mg; of vitamin E from 50 to 100 mg; of vitamin C from 10 to 30 mg; of capsaicin from 2 to 5 mg; of powdered wheat germs from 50 to 450 mg.
The composition according to the invention can be presented in capsules, pills, solution and emulsion. If in capsules or pills, the suggested dosage is one or two units, before meals.
Further object of the present invention is the use of the composition for the cancer treatment, in particular the treatment of prostate carcinoma. Moreover, the composition according to the invention can be advantageously employed for the treatment of skin diseases, in particular of psoriasis, for the treatment and the prevention from ageing, for the treatment and the prophylaxis of diseases .of the piliferous system, in particular of alopecia.
Another object of the present invention is a combination comprising resveratrol and curcumin for the simultaneous, separate or sequential use in the treatment of cancer, as for example, the prostate carcinoma, in the treatment of skin diseases as psoriasis and for the prevention and the treatment of alopecia.
The invention in fact can vary in its dosages and in its components, adding other components similar to the one suggested, but without altering the conceptual basis of the invention.
In this testing, apart from a relevant anti-cancer action on hormone-insensible prostate neoplasia, an effect on some patients has also been the stop of the hair loss and the growth of hair, sometimes of the original color too. Therefore patients without any neoplastic disease, but affected by alopecia or hair loss, have been included to the testing.
MATERIALS AND METHODS
The group treated only with resveratrol didn't show any relevant variation, except from two cases that showed a slight decrease.
Capsures of 4 pills a day let to a reduction in the level of PSA after 60 days to 7.4 and then to 6.80. The patient suffered also of psoriasis of the scalp, that disappeared after the treatment and that by now, after 8 months has not reappeared. Case 6: 64 years old man affected by prostratitis that tried various treatments. After the treatment with Capsures, 6 capsules a day, after 30 days had no more perineal pain and had a hair growth.
Case 14: 75 years old man, operated 4 years before for radical prostatectomy, intolerant to hormonal treatment he has been treated with Capsures, 4 pills a day for 60 days. His PSA value reduced from 4.5 to 2.4.
As far as its action on hair is concerned, some patients, especially women that were considerably loosing their hair, after 20 days of treatment confirmed to have had a reduction in their hair loss. In bald patients, the hair, sometimes of the original color restarted to grow even after the ablation of the white hair.
CONSIDERATIONS AND CONCLUSIONS
The compound containing just resveratrol as active agent (Resverage) didn't cause a reduction of the PSA value and this can be due to the low bioavailability of the molecule. In the cases of prostate carcinoma the efficacy of the association of resveratrol with curcumin can be due to a higher concentration in the circulation and therefore in the tissues explained by the lipophilia of the active elements of curcumin.
The association of resveratrol and curcumin seems to have a synergic effect that enhances the anti-inflammatory power of the two active elements. It is an essential activity because in the prostate carcinoma there is a phlogistic action caused by hyperincretion of enzymes as the cyclooxygenase 1 and 2.
As far as the action on hair is concerned, it is unquestionably due to the administration of the two combined active elements, since in the compound with just resveratrol no result has been shown and in the many cases in India and in Europe where Curcumin has been employed, any effect on hair has never been reported. The most important aspect rarely highlighted is that curcuminoids are capsaicinoid substances.
Those fibers, whose nerve cell is in the posterior roots, once stimulated release neuropeptides like the P substance, Neurokinin A and the Calcitonin Gene Related Peptide (CGRP). Experimental researches demonstrated that the desensibilization of those fibers leads to skin lesions localized in the cervical region of the rat. These experiments indicate the existence of a tropic function. It is probable that the loss of hair is a result of the deficit of neuropeptides released by the fibers that innervate the scalp.
Therefore it is possible that the administration of a substance that has as activity similar to capsaicin, as the Curcumin that metabolizes like an active curcumoid, can stimulate the sensorial fibers that have a tropic function, and that resveratrol has a vehicular function on the tissues. Therefore, the composition of the present invention is active on cases of hormone-insensible prostate carcinoma but in particular on hair, as our research has proven. The efficacy of the composition according to the present invention also depends on the great lyophilic properties of a capsaicinoid, curcumin on the anti-inflammatory effect of the two substances.
The interference of the hormonal action on hair loss is unquestionable, even if capsaicinoid-sensible sensory innervations are an ancestral phenomenon that does not depend on the hormonal mechanisms, but through a metabolic way different from the ordinary one. The growth and the pigmentation of the hair follicle seem to be controlled by epitelius-mesenchimoneuroechtodermmic interactions not very well known, but with an important role of the P substance on the hair growth in vivo.
Editor’s Comment- It would appear that based upon the data presented here , that a Curcumin/Resveratrol combo would be well worth integrating into one’s treatment regime. The beauty of the patent registry is that allows you to access usable information years ahead of commercial availability. In this case you don’t have to wait for “Capsures” to hit the market. You can easily put together and use a much higher dose and bio-available combination of Resveratrol and Curcumin at a fraction of the cost.
The long and short of it is that because these ingredients are not monitored by the FDA we can go ahead and take them and help to reverse hair loss. The supplements can be found in many health food stores but I find they are very expensive. Purchasing them online will save about 50% and I have a coupon code which will save an extra $5 for anyone looking to try out the Resvertrol and Curcumin together.
The ingredients from the study above can be found here: To save $5 enter the following code at checkout. LAT159
Now for some even better news. When you purchase the supplements from I-herb you will get your own promo code and you will save more money with any purchase. I find that any vitamin or natural product I find in health food stores average at least %48 cheaper online.
Enjoy your Optimized Resveratrol And Super Bio Curcumin and don't forget to save $5 by entering LAT159 at checkout
Stop hair loss
Stop Hair Loss
Hair Loss is one part of our life where men and women have always had equal share of difficulty.
Hair Loss is one part of our life where men and women have always had equal share of difficulty.
Although women mostly suffer from from problems like hair fall,split ends, early greying of hair,short lenght but there are generally spared from a more horrifying truth that most men have to go through is Baldness.
Various remedies, both artificial and natural, have been researched upon and discovered in these many years for this gruesome menace which is haunting the human race.Though over the years herbal and natural treatment to hair fall has seen attracting more patients. the shift is well explained as in matters to skin and hair treatment Ayurveda and Homeopathy has proved to be more fruitful than Common medicinal sciences(read alopathy).
Hence various institutes have come up guarenting you with a complete cure for hair loss.
A few options are listed down below:
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